Trimethoprim vs Varenicline

Interacting Drugs
Trimethoprim
vs
Varenicline
Security Level
Minor, Monitor Therapy
Mechanism
Varenicline: Trimethoprim may increase the serum concentration of Varenicline.
Management
Monitor for increased varenicline adverse effects with concomitant use of trimethoprim, particulary in patients with severe renal impairment. International product labeling recommendations vary. Consult appropriate labeling.

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