Interacting Drugs |
Trimethoprim vs Methotrexate |
Security Level |
 |
Mechanism |
Methotrexate: Trimethoprim may enhance the adverse/toxic effect of Methotrexate. |
Management |
Consider avoiding concomitant use of methotrexate and either sulfamethoxazole or trimethoprim. If used concomitantly, monitor for the development of signs and symptoms of methotrexate toxicity (e.g., bone marrow suppression). |
Trimethoprim vs Methotrexate
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Other Interactions of Trimethoprim
Other Interactions of Methotrexate
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