Sirolimus vs Itraconazole

Interacting Drugs
Sirolimus
vs
Itraconazole
Security Level
Moderate, Consider therapy modification
Mechanism
Itraconazole: May increase the serum concentration of Sirolimus.
Management
Sirolimus dose adjustments will likely be needed when starting/stopping any azole antifungal. Clinical data suggest sirolimus (adult) dose reductions of 50-90% will be needed when starting an azole antifungal, but specific guidelines are lacking.

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