Secobarbital vs HydrOXYzine

Interacting Drugs
Secobarbital
vs
HydrOXYzine
Security Level
Moderate, Consider therapy modification
Mechanism
HydrOXYzine: May enhance the CNS depressant effect of Barbiturates.
Management
Consider a decrease in the barbiturate dose, as appropriate, when used together with hydroxyzine. With concurrent use, monitor patients closely for excessive response to the combination.

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