Pralatrexate vs Nonsteroidal Anti-Inflammatory Agents

Interacting Drugs
Pralatrexate
vs
Nonsteroidal Anti-Inflammatory Agents
Security Level
Minor, Monitor Therapy
Mechanism
Nonsteroidal Anti-Inflammatory Agents: May increase the serum concentration of PRALAtrexate. More specifically, NSAIDS may decrease the renal excretion of pralatrexate.
Management
Closely monitor for increased pralatrexate serum levels and/or toxicity if used concomitantly with an NSAID. Monitor for decreased pralatrexate serum levels with NSAID discontinuation.

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Other Interactions of Pralatrexate

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Other Interactions of Nonsteroidal Anti-Inflammatory Agents

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