Interacting Drugs |
Phenytoin vs Vitamin K Antagonists (eg, warfarin) |
Security Level |
 |
Mechanism |
Vitamin K Antagonists (eg, warfarin): Phenytoin may enhance the anticoagulant effect of Vitamin K Antagonists. Vitamin K Antagonists may increase the serum concentration of Phenytoin. |
Management |
Anticoagulant dose adjustment will likely be necessary when phenytoin is initiated or discontinued. Monitor patients extra closely (INR and signs/symptoms of bleeding) when using this combination. |
Phenytoin vs Vitamin K Antagonists (eg, warfarin)
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Other Interactions of Phenytoin
Other Interactions of Vitamin K Antagonists (eg, warfarin)
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