Interacting Drugs |
Phenytoin vs Valproic Acid |
Security Level |
 |
Mechanism |
Valproic Acid: Phenytoin may increase the metabolism of Valproic Acid. A hepatotoxic metabolite of valproic acid may result. Valproic Acid may decrease the serum concentration of Phenytoin. Continued therapy usually yields a normalization (or slight increase) of serum phenytoin concentrations. Free phenytoin concentrations, however, tend to remain relatively stable (possibly increased with continued therapy). |
Management |
Monitor therapy |
Phenytoin vs Valproic Acid
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Other Interactions of Phenytoin
Other Interactions of Valproic Acid
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