Phenytoin vs Isoniazid

Interacting Drugs
Phenytoin
vs
Isoniazid
Security Level
Moderate, Consider therapy modification
Mechanism
Isoniazid: May increase the serum concentration of Phenytoin.
Management
Consider alternatives. If concomitant therapy cannot be avoided, monitor for increased phenytoin concentrations/effects with isoniazid initiation/dose increase, or decreased concentrations/effects with isoniazid discontinuation/dose decrease.

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Other Interactions of Phenytoin

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Other Interactions of Isoniazid

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