Phenytoin vs Calcium Channel Blockers

Interacting Drugs
Phenytoin
vs
Calcium Channel Blockers
Security Level
Moderate, Consider therapy modification
Mechanism
Calcium Channel Blockers: May increase the serum concentration of Phenytoin.
Management
Monitor for phenytoin toxicity with concomitant use of a calcium channel blocker (CCB) or decreased phenytoin effects with CCB discontinuation. Monitor for decreased CCB therapeutic effects. Nimodipine Canadian labeling contraindicates use with phenytoin. Exceptions: Clevidipine.

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Other Interactions of Phenytoin

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Other Interactions of Calcium Channel Blockers

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