Phenobarbital vs Maraviroc

Interacting Drugs
Phenobarbital
vs
Maraviroc
Security Level
Moderate, Consider therapy modification
Mechanism
Maraviroc: CYP3A4 Inducers (Strong) may decrease the serum concentration of Maraviroc.
Management
Increase maraviroc adult dose to 600 mg twice daily when used with strong CYP3A4 inducers. This does not apply to patients also receiving strong CYP3A4 inhibitors. Do not use maraviroc with strong CYP3A4 inducers in patients with Clcr less than 30 mL/min.

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