Phenobarbital vs Lapatinib

Interacting Drugs
Phenobarbital
vs
Lapatinib
Security Level
Major, Avoid combination
Mechanism
Lapatinib: CYP3A4 Inducers (Strong) may decrease the serum concentration of Lapatinib.
Management
If therapy overlap cannot be avoided, consider titrating lapatinib gradually from 1,250 mg/day up to 4,500 mg/day (HER2 positive metastatic breast cancer) or 1,500 mg/day up to 5,500 mg/day (hormone receptor/HER2 positive breast cancer) as tolerated.

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