Phenobarbital vs Gefitinib

Interacting Drugs
Phenobarbital
vs
Gefitinib
Security Level
Moderate, Consider therapy modification
Mechanism
Gefitinib: CYP3A4 Inducers (Strong) may decrease the serum concentration of Gefitinib.
Management
In the absence of severe adverse drug reactions, consider increasing gefitinib dose to 500 mg daily in patients receiving strong CYP3A4 inducers. Carefully monitor clinical response and development of adverse reactions.

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