Midazolam vs Telaprevir

Interacting Drugs
Midazolam
vs
Telaprevir
Security Level
Major, Avoid combination
Mechanism
Telaprevir: May increase the serum concentration of Midazolam.
Management
Use of oral midazolam with telaprevir is contraindicated. IV midazolam use may pose a lower risk, but dose reductions should be considered and patients should be monitored closely for signs/symptoms of toxicity.

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