Ketoconazole (systemic) vs Iloperidone

Interacting Drugs
Ketoconazole (systemic)
vs
Iloperidone
Security Level
Moderate, Consider therapy modification
Mechanism
Iloperidone: CYP3A4 Inhibitors (Strong) may increase serum concentrations of the active metabolite(s) of Iloperidone. Specifically, concentrations of the metabolites P88 and P95 may be increased. CYP3A4 Inhibitors (Strong) may increase the serum concentration of Iloperidone.
Management
Reduce iloperidone dose by half when administered with a strong CYP3A4 inhibitor.

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