Interacting Drugs |
Ketoconazole (systemic) vs Colchicine |
Security Level |
|
Mechanism |
Colchicine: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Colchicine. Colchicine distribution into certain tissues (e.g., brain) may also be increased. |
Management |
Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a p-glycoprotein inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed. |
Ketoconazole (systemic) vs Colchicine
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Other Interactions of Colchicine
Ketoconazole (systemic) vs Colchicine
Interacting Drugs |
Ketoconazole (systemic) vs Colchicine |
Security Level |
|
Mechanism |
Colchicine: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Colchicine. |
Management |
Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a strong CYP3A4 inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed. |
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Other Interactions of Colchicine
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