Ezetimibe and simvastatin vs Gemfibrozil

Interacting Drugs
Ezetimibe and simvastatin
vs
Gemfibrozil
Security Level
Major, Avoid combination
Mechanism
Gemfibrozil: May enhance the myopathic (rhabdomyolysis) effect of Simvastatin. Gemfibrozil may increase the serum concentration of Simvastatin. Concentrations of the active simvastatin acid metabolite may also be increased by gemfibrozil.
Management
Avoid combination

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