Ethacrynic acid vs Methotrexate

Interacting Drugs
Ethacrynic acid
vs
Methotrexate
Security Level
Moderate, Consider therapy modification
Mechanism
Methotrexate: May diminish the therapeutic effect of Loop Diuretics. Loop Diuretics may increase the serum concentration of Methotrexate. Methotrexate may increase the serum concentration of Loop Diuretics.
Management
Monitor for increased methotrexate and/or loop diuretic levels/toxicity with concomitant use of these agents and monitor for decreased therapeutic effects of loop diuretics. Methotrexate and/or loop diuretic dose reductions may be necessary.

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