Esomeprazole vs Clopidogrel

Interacting Drugs
Esomeprazole
vs
Clopidogrel
Security Level
Moderate, Consider therapy modification
Mechanism
Clopidogrel: Esomeprazole may decrease serum concentrations of the active metabolite(s) of Clopidogrel.
Management
Due to the possible risk for impaired clopidogrel effectiveness, clinicians should carefully consider the need for proton pump inhibitor therapy in patients receiving clopidogrel. Other acid-lowering therapies do not appear to share this interaction.

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