Therapeutic Class |
Antifungal Agent, Topical |
Indications |
Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea (pityriasis) versicolor. |
Adult Doses |
Tinea corporis/tinea cruris: Topical: Cream, lotion: Apply 1% cream to affected areas 1-2 times daily for 2 weeks Tinea pedis: Topical: Cream, lotion: Apply 1% cream to affected areas 1-2 times daily for 1 month Tinea versicolor: Topical: Cream: Apply 1% cream to affected areas once daily for 2 weeks Vaginal candidiasis: Vaginal : 600 mg pessary as a single dose. |
Contraindications |
Hypersensitivity to oxiconazole or any component of the formulation. |
Warnings / Precautions |
Pregnancy and lactation. Avoid contact with eyes. Intravaginal preparation may damage latex contraceptives. Discontinue if irritation or sensitisation occurs. Cross-sensitisation with other imidazole derivatives may occur. |
Adverse Reactions |
Pruritus, burning, irritation, stinging, erythema, rash, folliculitis, nodules, pain, papules, maceration, fissuring,allergic contact dermatitis, dyshidrotic eczema, tingling, dyshidrotic eczema, scaling, stinging, tingling. |
Mechanism of Actions |
Oxiconazole, a synthetic azole antifungal, is usually fungistatic but may be fungicidal in high concentrations. It exerts its antifungal activity by interfering with ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against aerobic gram-positive organisms. |
Pharmacodynamics |
Absorption: Absorbed in each dermis layer. |
Pregnancy Category |
B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. |
Lactation |
Enters breast milk/use caution. |
Storage Conditions |
Topical/Cutaneous: Store at 15-30°C (59-86°F). |
ATC Classification |
D01AC11 - oxiconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection. G01AF17 - oxiconazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections. |
GenericPedia Classification |
|
Storage |
Topical/Cutaneous: Store at 15-30°C (59-86°F). |
Available As |
|
Oxiconazole
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Oxiconazole Containing Brands
Oxiconazole is used in following diseases
Drug - Drug Interactions of Oxiconazole
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