Oxiconazole

Therapeutic Class
Antifungal Agent, Topical
Indications

Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea (pityriasis) versicolor.

Adult Doses

Tinea corporis/tinea cruris: Topical: Cream, lotion: Apply 1% cream to affected areas 1-2 times daily for 2 weeks

Tinea pedis: Topical: Cream, lotion: Apply 1% cream to affected areas 1-2 times daily for 1 month

Tinea versicolor: Topical: Cream: Apply 1% cream to affected areas once daily for 2 weeks

Vaginal candidiasis: Vaginal : 600 mg pessary as a single dose.

Contraindications

Hypersensitivity to oxiconazole or any component of the formulation.

Warnings / Precautions

Pregnancy and lactation. Avoid contact with eyes. Intravaginal preparation may damage latex contraceptives. Discontinue if irritation or sensitisation occurs. Cross-sensitisation with other imidazole derivatives may occur.

Adverse Reactions

Pruritus, burning, irritation, stinging, erythema, rash, folliculitis, nodules, pain, papules, maceration, fissuring,allergic contact dermatitis, dyshidrotic eczema, tingling, dyshidrotic eczema, scaling, stinging, tingling.

Mechanism of Actions

Oxiconazole, a synthetic azole antifungal, is usually fungistatic but may be fungicidal in high concentrations. It exerts its antifungal activity by interfering with ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against aerobic gram-positive organisms.

Pharmacodynamics

Absorption: Absorbed in each dermis layer.
Distribution: To each dermis layer.
Excretion: Via urine (<0.3%).

Pregnancy Category

B: Drug Pregnancy Category Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Lactation

Enters breast milk/use caution.

Storage Conditions

Topical/Cutaneous: Store at 15-30°C (59-86°F).

ATC Classification
D01AC11 - oxiconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
G01AF17 - oxiconazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.
GenericPedia Classification
  • ,
  • Storage

    Topical/Cutaneous: Store at 15-30°C (59-86°F).

    Available As
  • Oxiconazole 1%
  • Oxiconazole 1% w/w
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