Therapeutic Class |
Antidote |
Indications |
Antidote for cyanide poisoning and drug-induced methemoglobinemia, indicator dye. Unlabeled/Investigational: Treatment/prevention of ifosfamide-induced encephalopathy; topically, in conjunction with polychromatic light to photoinactivate viruses such as herpes simplex; alone or in combination with vitamin C for the management of chronic urolithiasis. |
Adult Doses |
I.V.: Methemoglobinemia: 1-2 mg/kg or 25-50 mg/m2 over 5-10 minutes; may be repeated in 1 hour if necessary. |
Contraindications |
Hypersensitivity to methylene blue or any component of the formulation; intraspinal injection; renal insufficiency. |
Warnings / Precautions |
Anemia, Methemoglobinemia, Renal impairment, Serotonin modulators, G6PD deficiency, Young patients, Do not inject SubQ or intrathecally ,should not be added to enteral feeding products. |
Adverse Reactions |
Cardiovascular: Hypertension, precordial pain Central nervous system: Dizziness, headache, fever, mental confusion Dermatologic: Staining of skin Gastrointestinal: Abdominal pain, fecal discoloration (blue-green), nausea, vomiting Genitourinary: Bladder irritation, discoloration of urine (blue-green) Hematologic: Anemia, transient reduction in oxygen saturation as read by pulse oximetry Miscellaneous: Diaphoresis, Serotonin syndrome |
Mechanism of Actions |
Weak germicide in low concentrations, hastens the conversion of methemoglobin to hemoglobin; has opposite effect at high concentrations by converting ferrous ion of reduced hemoglobin to ferric ion to form methemoglobin; in cyanide toxicity, it combines with cyanide to form cyanmethemoglobin preventing the interference of cyanide with the cytochrome system. |
Pharmacodynamics |
Onset of action: Reduction of methemoglobin: I.V.: 30-60 minutes Absorption: Oral: 53% to 97% Metabolism: Peripheral reduction to leukomethylene blue Excretion: In bile, feces, and urine as leukomethylene blue |
Monitoring |
Arterial blood gases; cardiac monitoring (patients with pre-existing pulmonary and/or cardiac disease); CBC; methemoglobin levels (co-oximetry yields a direct and accurate measure of methemoglobin levels); pulse oximeter (will not provide accurate measurement of oxygenation when methemoglobin levels are >35%); renal function; signs and symptoms of methemoglobinemia such as pallor, cyanosis, nausea, muscle weakness, dizziness, confusion, agitation, dyspnea, and tachycardia; transcutaneous O2 saturation |
Administration |
I.V.: Administer undiluted by direct I.V. injection over 5-10 minutes. Consider concomitant dextrose administration, especially in patients who are hypoglycemic, to ensure efficacy of methylene blue. |
Pregnancy Category |
C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. |
ATC Classification |
V03AB17,V04CG05 |
GenericPedia Classification |
Methylene blue
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Methylene blue Containing Brands
Methylene blue is used in following diseases
Drug - Drug Interactions of Methylene blue
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