Xipamide

Indications
 Oral
Oedema
Adult: Initially, 40 mg daily in the morning, reduced to 20 mg daily according to response. Max: 80 mg daily.
Renal impairment: Severe: Avoid.
Hepatic impairment: Caution in use.
Oral
Hypertension
Adult: 20 mg daily as a single dose in the morning.
Renal impairment: Severe: Avoid.
Hepatic impairment: Caution in use.

Reconstitution: Ref: See PI.
Contraindications
 Hypersensitivity to sulphonamide. Untreated Addison's disease. Severe renal failure; severe electrolyte deficiency; precomatose states associated with cirrhosis; lactation.
Warnings / Precautions
 Pregnancy; elderly. Prostatic hypertrophy; renal or hepatic impairment; hypovolaemia; DM; hyperuricaemia; severe coronary or cerebral arteriosclerosis.
Adverse Reactions
 GI disturbances; hypokalaemia; hyperuricaemia; nocturia, dizziness; impaired glucose metabolism.
Overdose Reactions
 Symptoms: Hypotension, electrolyte and metabolic disturbances. Management: Reduce further absorption by gastric lavage or induced emesis. Treatment is supportive with BP maintenance and correction of electrolyte imbalances.
Drug Interactions
 Antihypertensives enhance BP-lowering effects of xipamide. Increased risk of hypokalaemia with amphotericin B, carbenoxolone.
Potentially Fatal: Propensity to cause hypokalaemia can increase risk of digitalis toxicity.
See Below for More xipamide Drug Interactions
Mechanism of Actions
 Xipamide is structurally related to indapamide and exerts its diuretic effect at the distal section of the nephron.
Onset: 1-2 hr
Duration: 12 hr
Absorption: Rapid and well absorbed from GI tract. Peak plasma concentration: 1-2 hr.
Distribution: Protein binding: 99%.
Excretion: Excreted in urine as unchanged and glucuronide metabolite. Plasma half life: 5-8 hr.
ATC Classification
 C03BA10 - xipamide ; Belongs to the class of low-ceiling sulfonamide diuretics.
Available As
  • Xipamide 20 mg

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