Valethamate

Indications
 Oral
Dysmenorrhoea
Adult: Each tablet contains 10 mg valethamate bromide and 325 mg paracetamol. 1 tablet tid.
Oral
Postoperative pain
Adult: Each tablet contains 10 mg valethamate bromide and 325 mg paracetamol. 1 tablet tid.
Oral
Visceral spasms
Adult: Each tablet contains 10 mg valethamate bromide and 325 mg paracetamol. 1 tablet tid.
Oral
Gastrointestinal tract spasm
Adult: Each tablet contains 10 mg valethamate bromide and 325 mg paracetamol. 1 tablet tid.
Oral
Tenesmus
Adult: Each tablet contains 10 mg valethamate bromide and 325 mg paracetamol. 1 tablet tid.
Oral
Urinary tract and bile stone colic
Adult: Each tablet contains 10 mg valethamate bromide and 325 mg paracetamol. 1 tablet tid.
Parenteral
Dysmenorrhoea
Adult: 8-16 mg daily, via IM or IV inj.
Parenteral
Visceral spasms
Adult: 8-16 mg daily, via IM or IV inj.
Parenteral
Gastrointestinal tract spasm
Adult: 8-16 mg daily, via IM or IV inj.
Parenteral
Urinary tract and bile stone colic
Adult: 8-16 mg daily, via IM or IV inj.
Contraindications
 Narrow angle glaucoma, benign prostatic hyperplasia, paralytic ileus, pyloric stenosis, ulcerative colitis, megacolon, tachyarrhythmia. Severe hepatic and renal impairment.
Warnings / Precautions
 May impair ability to drive or operate machinery at high doses.
Adverse Reactions
 Dry mouth, blurring of vision, difficulty in swallowing and talking, constipation, urinary retention, mydriasis, arrhythmias.
Drug Interactions
 Increased antimuscarinic side effects with drugs with antimuscarinic properties e.g. amantadine, antihistamines, phenothiazide antipsychotics, TCAs. Antagonise GI effects of domperidone, metoclopramide. Delayed gastric emptying reduces absorption of other drugs.
See Below for More valethamate Drug Interactions
Mechanism of Actions
 A quaternary ammonium anticholinergic with peripheral actions close to those of atropine.
Storage Conditions
 Oral: Store below 25°C. Parenteral: Store below 25°C.
Storage
 Oral: Store below 25°C. Parenteral: Store below 25°C.
Available As
  • Valethamate 10 mg
  • Valethamate 8 mg

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