Indications |
Oral Heart failure Adult: 50-150 mg daily in 2-3 divided doses. Oral Angina pectoris Adult: 150-600 mg daily in divided doses. |
Warnings / Precautions |
Avoid intense exercise during ubidecarenone therapy. |
Adverse Reactions |
Gastric discomfort, anorexia, diarrhoea, nausea, skin rash, heart burn. Increase in LFT with doses >300 mg/day. |
Drug Interactions |
Decreased serum levels with statins. Possible decrease in INR with warfarin. See Below for More ubidecarenone Drug Interactions |
Mechanism of Actions |
Ubidecarenone (also known as ubiquinone or coenzyme Q10) is a naturally occurring coenzyme structurally similar to vitamin K. It is involved in electron transport and energy production in the mitochondria. Although found in all human cells, it is present in high concentrations in the heart, kidney, liver and pancreas. It is also found in dietary supplements and has been tried in conditions associated with coenzyme deficiency and also as an adjunct in CV disorders including mild or moderate heart failure. Absorption: Poor and slow GI absorption; absorption increased with high fat food. Distribution: May undergo enterohepatic recycling. Plasma half life: 34 hr. Metabolism: Extent of hepatic metabolism unknown. Excretion: Mainly via bile, with >60% excreted unchanged in faeces. |
Administration |
Should be taken with food. (Take after meals.) |
ATC Classification |
C01EB09 - ubidecarenone ; Belongs to the class of other cardiac preparations. |
Available As |
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Ubidecarenone
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Ubidecarenone Containing Brands
Ubidecarenone is used in following diseases
Drug - Drug Interactions of Ubidecarenone
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