Tripelennamine Hcl

Indications
 Oral
Hypersensitivity reactions
Adult: As hydrochloride: 25-50 mg every 4-6 hr. Max: 600mg daily.
Child: As hydrochloride: 5 mg/kg in 4-6 divided doses daily. Max: 300mg daily.
Contraindications
 Neonates.
Warnings / Precautions
 Narrow-angle glaucoma, urinary retention, prostatic hypertrophy, pyloroduodenal obstruction, epilepsy. Avoid operating vehicles or machinery. Elderly.
Adverse Reactions
 Sedation; CNS depression; antimuscarinic effects; GI disturbances.
Potentially Fatal: Blood dycrasias.
Drug Interactions
 Increased sedation with CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytics, sedatives and antipsychotics. Increased antimuscarinic side effects with other antimuscarinic drugs e.g. atropine, TCAs and MAOIs. May mask signs of ototoxicity caused by aminoglycosides.
See Below for More tripelennamine Drug Interactions
Lab Interactions
 May suppress histamine response to allergens and thus may interfere with skin testing.
Mechanism of Actions
 Tripelennamine is an antihistamine derived from ethylenediamine with antimuscarinic and moderate sedative properties.
ATC Classification
 D04AA04 - tripelennamine ; Belongs to the class of topical antihistamines used in the treatment of pruritus.
R06AC04 - tripelennamine ; Belongs to the class of substituted ethylene diamines used as systemic antihistamines.
Available As
  • Tripelennamine Hcl 2%

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