Trifluopromazine

Indications
 Intramuscular
Psychoses
Adult: 60-150 mg daily.
Child: IM: >2½ yr: 200-250 mcg/kg daily. Max: 10mg daily.
Elderly: or debilitated patients: Dose reduction is recommended.
Parenteral
Nausea and vomiting
Adult: IV: 1 mg/dose; max: 3 mg daily. IM: 5-15 mg, repeated after 4 hr if necessary; max: 60 mg daily.
Child: IM: >2½ yr: 200-250 mcg/kg daily. Max: 10mg daily.
Elderly: or debilitated patients: Dose reduction is recommended.
Contraindications
 Preexisting CNS depression and coma; bone marrow depression, blood dyscrasias, liver disease, hypersensitivity to phenothiazines, prolactin dependent tumours. Pregnancy (1st trimester), lactation.
Warnings / Precautions
 Cardiovascular disease, epilepsy, angle-closure glaucoma, exposure to extreme temperatures, parkinson's disease, myasthenia gravis, benign prostatic hyperplasia, DM, renal amd hepatic impairment. Discontinue triflupromazine at least 48 hr before myelography and do not resume for at least 24 hr after procedure. Do not use in control of nausea and vomiting occurring either prior to myelography or postprocedure with metrizamide. Pregnancy, elderly.
Adverse Reactions
 Blurred vision, dry mouth, urinary hesitancy/retention, constipation, orthostatic hypotension, allergic rash, akathisia, dystonias, muscle weakness, anorexia, insomnia.
Potentially Fatal: Blood dyscrasias, malignant neuroleptic syndrome.
Drug Interactions
 Increased CNS depression with CNS depressants such as opiates or other analgesics, barbiturates or other sedatives, general anaesthetics, or alcohol. Increased risk of side effects with drugs with antimuscarinic properties e.g. TCA, antiparkinsonian drugs. Antagonised effects of dopaminergic drugs such as levodopa. Increased risk of hypotension with antihypertensives, trazodone. Reverses antihypertensive effect of guanethidine. Increased risk of severe extrapyramidal side-effects or severe neurotoxicity with lithium. Possible decrease in absorption with antacids.
See Below for More triflupromazine Drug Interactions
Mechanism of Actions
 Triflupromazine is a phenothiazine with general properties similar with chlorpromazine.
ATC Classification
 N05AA05 - triflupromazine ; Belongs to the class of phenothiazine antipsychotics with aliphatic side-chain.
Available As
  • Trifluopromazine 10 mg
  • Trifluopromazine 100 mg

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