Tolfenamic Acid

Indications
 Oral
Acute migraine attacks
Adult: 200 mg when 1st symptoms appear, may be repeated once after 1-2 hr.
Renal impairment: Dose adjustments may be needed. Severe: Avoid.
Oral
Mild to moderate pain
Adult: 100-200 mg tid.
Renal impairment: Dose adjustments may be needed. Severe: Avoid.
Contraindications
 Hypersensitivity to aspirin or other NSAID. Active peptic ulceration. Severe renal or hepatic impairment. Pregnancy (3rd trimester).
Warnings / Precautions
 Asthma, bronchospasm, bleeding disorders, CV diseases, history of peptic ulceration, hypertension, patients with infections, liver, cardiac, or renal function impairment. Increase water intake or dose reduction to reduce dysuria. CHF; elderly; lactation.
Adverse Reactions
 Dysuria especially in males; diarrhoea, nausea, epigastric pain, vomiting, dyspepsia, erythema, headache. Tremor, euphoria, fatigue, pulmonary infiltration.
Potentially Fatal: Blood dyscrasias, toxic hepatitis.
Drug Interactions
 Increased rate of absorption of tolfenamic acid with metoclopramide and magnesium hydroxide. Decreased rate of absorption of tolfenamic acid with aluminium hydroxide. Increased risk of bleeding with anticoagulants and other NSAIDs. Decreased antihypertensive response to loop diuretics, β-blockers and ACE inhibitors. Coadmin increased plasma concentrations of lithium, methotrexate and cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus or diuretics.
See Below for More tolfenamic acid Drug Interactions
Lab Interactions
 May interfere with thyroid function test as it may lower serum thyroid hormone concentrations.
Mechanism of Actions
 Tolfenamic acid, an anthranilic acid derivative, is an NSAID. It has anti-inflammatory, analgesic and antipyretic effects.
Absorption: Readily absorbed from GI tract. Peak plasma concentration: 60-90 min. Bioavailability: 85%.
Distribution: Protein-binding: 99%. Plasma half-life: 2 hr. Distributed into breast milk.
Metabolism: Metabolised in the liver. Undergoes enterohepatic circulation.
Excretion: Excreted in urine (90%) and faeces.
Administration
 Should be taken with food. (Take w/ or immediately after meals.)
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 M01AG02 - tolfenamic acid ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, fenamates.
Storage
 Oral: Store below 25°C.
Available As
  • Tolfenamic Acid 200 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Tolfenamic Acid


    Tolfenamic Acid Containing Brands

    We are Developing Our database, More results coming soon.

    Tolfenamic Acid is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Tolfenamic Acid

    We are Developing Our database, More results coming soon.