Tianeptine

Indications	Oral Depression *Adult:* 12.5 mg tid. *Elderly:* Dose reduction to total daily dose of 25 mg. *Renal impairment:* Reduce total daily dose to 25 mg/day. *Special Populations:* Patients with renal impairment: Total daily dose of 25 mg daily. No dose modification in patients with chronic alcoholism or cirrhosis.
Contraindications	Childn <15 yrs. Pregnancy and lactation.
Warnings / Precautions	General anaesthesia; tasks requiring mental alertness. Avoid abrupt withdrawal, dosage to be decreased gradually over 7-14 days.
Adverse Reactions	Abdominal pain, fatigue, nausea, constipation, lack of appetite, insomnia, drowsiness, palpitations, muscular or joint pain, headache, vertigo, tremour, dry mouth, hepatitis (rare)
Overdose Reactions	Gastric lavage followed by symptomatic treatment and monitoring of CV, respiratory, metabolic and renal function.
Drug Interactions	Potentially Fatal: Avoid concurrent admin with MAOI, start tianeptine 2 wk after discontinuation from MAOI. See Below for More tianeptine Drug Interactions
Food Interactions	Decreased absorption with alcohol.
Mechanism of Actions	Tianeptine exerts its antidepressant action by increasing the presynaptic re-uptake of serotonin.
Administration	Should be taken on an empty stomach. (Take before main meals.)
Storage Conditions	Oral: Store below 30°C.
ATC Classification	N06AX14 - tianeptine ; Belongs to the class of other antidepressants.
Storage	Oral: Store below 30°C.
Available As	Tianeptine 12.5 mg

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