Movement disorders
Adult: Initially 12.5 mg bid, increased gradually to 12.5-25 mg tid. Max: 200mg daily. If no improvement at max dose for 7 days, drug unlikely to be of benefit.
Elderly: Initially 12.5 mg daily, increased gradually.
Moderate to severe tardive dyskinesia
Adult: Initially 12.5 mg daily increased gradually according to response.
Warnings / Precautions
May exacerbate symptoms of parkinsonism. Caution to be exercised when driving or performing skilled tasks. Pregnancy.
Adverse Reactions
Drowsiness, extrapyramidal symptoms, parkinsonism, depression, orthostatic hypotension, GI disturbances.
Potentially Fatal: Neuroleptic malignant syndrome (NMS).
Overdose Reactions
Drowsiness, sweating, hypotension, and hypothermia. Supportive and symptomatic treatment.
Drug Interactions
Tetrabenazine should not be given with or within 14 days of discontinuation of MAOI therapy. Blocks action of reserpine. Decreases effects of levodopa and worsen parkinsonism. Increased risk of extrapyramidal side effects when given with amantadine, metoclopramide, antipsychotics.
See Below for More tetrabenazine Drug Interactions
Mechanism of Actions
Tetrabenazine act by depleting nerve endings of dopamine in the brain and is used to control movement disorders.
Absorption: Poorly and erratically absorbed from the GIT (oral).
Metabolism: Extensive hepatic first-pass metabolism reduced to hydroxytetrabenazine.
Excretion: Via urine (as metabolites).
May be taken with or without food.
Storage Conditions
Oral: Store below 30°C.
ATC Classification
N07XX06 - tetrabenazine ; Belongs to the class of other nervous system drugs.
Oral: Store below 30°C.
Available As
  • Tetrabenazine 25 mg
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