Terconazole

Indications	Vaginal Vulvovaginal candidiasis *Adult:* 40 mg (as 0.8% vag cream) or 80 mg (as pessary) at bedtime for 3 consecutive nights or 20 mg (as 0.4% cream) at bedtime for 7 consecutive nights.
Contraindications	Hypersensitivity. Lactation.
Warnings / Precautions	Discontinue if irritation or flu-like symptoms develop. May damage latex or rubber contraceptives. Patients <18 yrs. Pregnancy.
Adverse Reactions	Vulvovaginal burning, vulvar itching, dysmenorrhoea, genital, body and abdominal pain. Flu-like syndrome with headache, fever, chills and hypotension with doses >80 mg.
Mechanism of Actions	Terconazole disrupts ergosterol synthesis by binding to fungal cytochrome P450. It is active in vitro against Candida spp and other fungi. It has some antibacterial activity in vitro but not against usual vag flora eg, lactobacilli. Absorption: Intravaginal: 5-16% absorbed Metabolism: Hepatic metabolism Excretion: Excreted in urine and faeces.
Storage Conditions	Vaginal: Store between 15-30°C.
ATC Classification	G01AG02 - terconazole ; Belongs to the class of triazole derivative antiinfectives. Used in the treatment of gynecological infections.
Storage	Vaginal: Store between 15-30°C.
Available As	Terconazole 0.8% w/w Terconazole 80 mg

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