Tenoxicam

Indications
 Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: 20 mg as a single daily dose given for 7 days in acute musculoskeletal disorders and up to 14 days in severe cases. Max: 40 mg/day (short term use).
Parenteral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: Initially, 20 mg IM/IV as a single dose given for 1-2 days.
Contraindications
 Active or history of recurrent GI bleed or peptic ulcer, hypersensitivity to NSAIDs, severe heart failure, haemorrhagic diathesis, asthma, pregnancy (3rd trimester).
Warnings / Precautions
 History of peptic ulceration, renal, cardiac or hepatic impairment, cerebovascular disease, fluid retention, inflammatory bowel disease, pregnancy, elderly.
Adverse Reactions
 GI upsets including epigastric pain and gastritis, nausea, hypersensitivity reactions, headache, dizziness, sleep disturbances.
Potentially Fatal: CV thrombotic events, blood dyscrasias, nephrotoxicity, hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome.
Drug Interactions
 Risk of nephrotoxicity may be increased with ACE inhibitors, ciclosporin, tacrolimus or diuretics. Increased risk of hyperkaelemia with ACE inhibitors, potassium sparing diuretics.
Potentially Fatal: Concurrent use increased concentrations of lithium, methotrexate, cardiac glycoside; increased risk of bleeding with anticoagulants and other NSAIDs.
See Below for More tenoxicam Drug Interactions
Food Interactions
 Absorption slowed but overall bioavailability not reduced.
Mechanism of Actions
 Tenoxicam is a potent inhibitor of prostaglandin synthesis by blocking the enzyme cyclo-oxygenase. Additional actions contributing to its anti-inflammatory effect includes inhibition of leucocyte function including phagocytosis and chemotaxis, and scavenging free O2 radicals. It has no effect on renal function at the usual doses.
Absorption: Absorbed well from the GIT (oral); peak plasma concentrations after 2 hr (fasting), 6 hr (non-fasting).
Distribution: Penetrates synovial fluid. Protein-binding: 98.5%
Metabolism: Hepatic; completely to inactive metabolites.
Excretion: Via urine (as metabolites), via bile (as conjugates of the metabolites); 60-75 hr (elimination half-life)
Administration
 Should be taken with food. (Take w/ or immediately after meals.)
Storage Conditions
 Oral: Do not store above 30°C Parenteral: Do not store above 30°C
ATC Classification
 M01AC02 - tenoxicam ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, oxicams.
Storage
 Oral: Do not store above 30°C Parenteral: Do not store above 30°C
Available As
  • Tenoxicam 20 mg

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