Suxamethonium Chloride

Indications
 Intravenous
Muscle relaxant in general anaesthesia
Adult: As chloride: single dose of 0.3-1.1 mg/kg injected; supplementary doses of 50-100% of the initial dose may be given at 5-10 min intervals. Max dose (repeated IV injection or continuous infusion): 500 mg/hr
Child: As chloride: <1 yr: 2 mg/kg; 1-12 yr: 1 mg/kg.
Intramuscular
Muscle relaxant in general anaesthesia
Adult: As chloride: 3-4 mg/kg. Max total dose: 150 mg
Child: As chloride: <1 yr: Up to 4-5 mg/kg; ≥1 yr: Up to 4 mg/kg. Max dose: 150 mg.

Reconstitution: IV infusion: dilute to a concentration of 1-2 mg/ml (0.1-0.2%) with 5% dextrose, 5% dextrose and 0.9% sodium chloride, 0.9% sodium chloride, (1/6) M sodium lactate; given at a rate 0.5-10 mg/min depending on the response and requirements of patient.
Incompatibility: Alkaline solutions with pH>8.5 .
Contraindications
 Genetic disorders of plasma pseudocholinesterase, personal/family history of malignant hyperthermia, hypersensitivity from previous neuromuscular drug, severe burns, massive trauma, extensive denervation of skeletal muscle, patients with risk of hyperkalaemia, renal impairment, angle closure glaucoma.
Warnings / Precautions
 Bone fracture, raised intraocular pressure, neuromuscular disease, infants, childn, adolescents, pregnancy and lactation.
Adverse Reactions
 Bradycardia, tachycardia, hypotension, hyperpertension, raised intraocular pressure, hyperkalaemia, excessive salivation.
Potentially Fatal: Respiratory depression, dysrhythmias, rhabdomyolsis, malignant hyperthermia.
Drug Interactions
 Concurrent use with anticholinesterases, cyclophosphamide, antiarrhythmics, aminoglycosides, lincosamides (clindamycin and lincomycin), anticonvulsants, phenelzine, magnesium, metoclopramide, inhalation anaesthetics, exposure to organophosphate insecticides may enhance neuromuscular block of suxamethonium. Increased risk of arrhythmias with cardiac glycosides.
See Below for More suxamethonium chloride Drug Interactions
Mechanism of Actions
 Suxamethonium chloride is an ultrashort-acting depolarising type skeletal muscle relaxant. It blocks the neuromuscular junction by binding to the cholinergic receptors and depolarising it.
Onset: IV: 30-60 sec; IM: 2-3 min
Duration: IV: 2-6 min; IM: 10-30 min
Distribution: Small amounts of suxamethonium cross the placenta
Metabolism: Rapidly hydrolysed by plasma cholinesterase.
Excretion: 10% excreted unchanged in urine.
Storage Conditions
 Intramuscular: Refrigerate at 2-8°C. Intravenous: Refrigerate at 2-8°C.
Storage
 Intramuscular: Refrigerate at 2-8°C. Intravenous: Refrigerate at 2-8°C.
Available As
  • Suxamethonium Chloride 50 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Suxamethonium Chloride


    Suxamethonium Chloride Containing Brands

    We are Developing Our database, More results coming soon.

    Suxamethonium Chloride is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Suxamethonium Chloride

    We are Developing Our database, More results coming soon.