Spectinomycin

Indications
 Intramuscular
Gonorrhoea
Adult: 2 g as single dose. In cases whereby antibiotic resistance is prevalent, 4 g (10 ml) may be given but divided as two 5 ml inj, admin to 2 different inj sites.
Child: <45 kg: 40 mg/kg as a single dose. ≥45 kg: 2 g as single dose. In cases whereby antibiotic resistance is prevalent, 4 g (10 ml) may be given but divided as two 5 ml inj, admin to 2 different inj sites.
Intramuscular
Disseminated gonococcal infection
Adult: 2 g every 12 hr.

Reconstitution: Reconstitute with supplied diluent only.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Repeated doses may lead to changes in the kidney and liver function and a reduction in haemoglobin and haematocrit levels. Prolonged use may result in fungal or bacterial superinfection. All patients with gonorrhoea should be tested for syphilis at the time of diagnosis.
Adverse Reactions
 Dizziness; nausea; urticaria; chills; fever; headache, insomnia, mild to moderate pain after inj.
Potentially Fatal: Anaphylaxis.
Drug Interactions
 May result in lithium toxicity when used concurrently.
See Below for More spectinomycin Drug Interactions
Mechanism of Actions
 Spectinomycin binds to 30S subunit of the bacterial ribosome, thus inhibiting protein synthesis. It has modest activity against a wide range of gram-positive and gram-negative organisms, though anaerobic organisms are mostly resistant.
Absorption: Poorly absorbed after oral admin but rapidly absorbed after IM inj.
Distribution: Poor distribution into the saliva. Poorly bound to plasma proteins.
Excretion: Excreted in an active form in the urine. Half-life: 1-3 hr; may be prolonged in renal impairment.
Storage Conditions
 Intramuscular: Store at 20-25°C. Reconstituted solutions should be used within 24 hr after preparation.
ATC Classification
 J01XX04 - spectinomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Storage
 Intramuscular: Store at 20-25°C. Reconstituted solutions should be used within 24 hr after preparation.
Available As
  • Spectinomycin 200 mg
  • Spectinomycin 2000 mg

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