Sodium Hyaluronate

Indications
Intra-articular
Osteoarthritis of the knee
Adult: 20-25 mg once wkly for 5 wk or up to 30 mg once wkly for 3-4 wk. Not to repeat treatment course within 6 mth for any individual joint.
Ophthalmic
Surgical aid in the anterior segment during cataract extraction and intraocular lens implantation
Adult: Slowly admin a sufficient quantity into the eye.
Topical/Cutaneous
Skin ulcers and wounds
Adult: As cream, gel or spray: Apply a thin layer onto clean and disinfected wound/ulcer bid-tid. Cover with sterile, non-stick dressing.
Contraindications
Hypersensitivity to sodium hyaluronate or avian proteins.
Warnings / Precautions
Monitor intraocular pressure. Pregnancy.
Adverse Reactions
Ophthalmic: Transient rise in intraocular pressure. Intra-articular inj: Pain and inflammation at inj site. Hypersensitivity; anaphylaxis; hypotensive crisis.
Mechanism of Actions
Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.
Distribution: Widely distributed in body tissues and intracellular fluids.
Excretion: Ophthalmic, via Canal of Schlemm.
Storage Conditions
Intra-articular: Store at 2-25°C. Ophthalmic: Store at 2-25°C. Topical/Cutaneous: Store at 2-25°C.
Storage
Intra-articular: Store at 2-25°C. Ophthalmic: Store at 2-25°C. Topical/Cutaneous: Store at 2-25°C.
Available As
  • Sodium Hyaluronate 0.1%
  • Sodium Hyaluronate 0.15%
  • Sodium Hyaluronate 0.18%
  • Sodium Hyaluronate 0.5%
  • Sodium Hyaluronate 1% w/v
  • Sodium Hyaluronate 10 mg
  • Sodium Hyaluronate 25 mg
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