Sisomycin

Indications
 Intramuscular
Susceptible Gram-negative and staphylococcal infections
Adult: 3 mg/kg daily in 2-3 divided doses. May also be given as IV infusion, if needed.
Renal impairment: May need to adjust maintenance doses and/or dosing intervals.
Topical/Cutaneous
Pyoderma
Adult: As 0.1% cream: Apply onto the affected area(s) bid.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Renal or liver impairment, myasthenia gravis, parkinsonism, dehydration, hypotension, pregnancy, lactation.
Adverse Reactions
 Ototoxicity, nephrotoxicity, neurotoxicity (peripheral neuropathy, confusion, lethargy, hallucination, convulsion and mental depression, occasional respiratory depression), rarely hypersensitivity reaction.
Potentially Fatal: Acute renal failure especially in combination with other nephrotoxic drugs.
Drug Interactions
 Plasma levels increased by indometacin. Antihistamines (H1-receptor blocker) may mask early signs of ototoxicity. Incompatible with some β-lactam antibiotics.
Potentially Fatal: Potentiates nephrotoxicity produced by other nephrotoxic drugs including other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid. Ototoxicity potentiated by furosemide.
See Below for More sisomicin Drug Interactions
Mechanism of Actions
 Sisomicin binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
ATC Classification
 J01GB08 - sisomicin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.
Available As
  • Sisomycin 0.1%
  • Sisomycin 0.1% w/w
  • Sisomycin 1 mg
  • Sisomycin 10 mg
  • Sisomycin 3 mg
  • Sisomycin 50 mg

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