Sennosides

Indications	Oral Constipation *Adult:* 15-30 mg (as total sennosides) 1-2 times daily. *Child:* 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime. Oral Bowel evacuation *Adult:* 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
Contraindications	Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.
Warnings / Precautions	Inflammatory bowel disease. Avoid prolonged use.
Adverse Reactions	Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.
Mechanism of Actions	Sennosides A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna. Duration: 6-12 hr. Absorption: Some absorption following oral admin. Distribution: Enters the breast milk. Metabolism: Unabsorbed senna undergoes hydrolysis in the colon to release the active anthraquinones while absorbed senna undergoes hepatic metabolism. Excretion: Excreted in the urine & faeces.
Available As	Sennosides 11.5 mg Sennosides 12 mg Sennosides 18 mg Sennosides 7.5 mg

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