Rupatadine

Indications
 Oral
Allergic rhinitis, Chronic idiopathic urticaria
Adult: 10 mg once daily.
Contraindications
 Hypersensitivity. Avoid alcohol.
Warnings / Precautions
 Renal or hepatic insufficiency. May impair ability to drive or operate machinery. Pregnancy, lactation. Elderly, children <12 yr.
Adverse Reactions
 Headache, somnolence, fatigue/asthenia.
Drug Interactions
 Increased CNS depressant effects when used with CNS depressants or alcohol.
See Below for More rupatadine Drug Interactions
Mechanism of Actions
 Rupatadine acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors. Rupatadine also antagonises the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction and lead to an increase in the vascular permeability, acting as mediators in the inflammatory process.
Metabolism: Liver - mainly by CYP450.
ATC Classification
 R06AX28 - rupatadine ; Belongs to the class of other antihistamines for systemic use.
Available As
  • Rupatadine 10 mg

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