Rizatriptan

Indications
 Oral
Acute migraine attacks
Adult: Initially, 10 mg. If ineffective, 2nd dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hr. Max: 20 mg/24 hr. If patient is also taking propanolol, initiate with 5 mg. Max: 10 mg/24 hr. Ensure that the 2 drugs are separated by at least 2 hr.
Renal impairment: For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.
Hepatic impairment: For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.

Special Populations: In patients with mild to moderate hepatic or renal impairment: Dose reduction to 5 mg. For recurrence of headache: Further dose of 5 mg after 2-hr interval. Max dose: 10 mg/day. In patients receiving propranolol: Similar dose reduction; 2 drugs should be separated for at least 2 hrs.
Contraindications
 History of MI, peripheral vascular disease, transient ishaemic attack, ischaemic heart disease or Prinzmetal's angina; uncontrolled hypertension; basilar or hemiplegic migraine; severe hepatic or renal impairment. Adolescent <18 yr.
Warnings / Precautions
 Elderly; mild to moderate hepatic or renal impairment; coronary artery disease; pregnancy, lactation. May cause drowsiness. History of seizures. Ensure an interval of at least 24 hr after stopping an ergotamine compound and starting a serotonin (5-HT1) agonist.
Adverse Reactions
 Increased BP, chest pain, palpitation; skin flushing; dyspnoea; nausea, abdominal pain, dry mouth; dizziness, drowsiness, fatigue.
Potentially Fatal: Toxic epidermal necrolysis.
Overdose Reactions
 May cause hypertension and CV symptoms. Gastric lavage using activated charcoal may be considered. Monitor ECG and clinical status of the patient.
Drug Interactions
 Increased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome.
Potentially Fatal: Concurrent use with or within 2 wk of stopping MAOI treatment.
See Below for More rizatriptan Drug Interactions
Food Interactions
 Absorption delayed. Concurrent use with St John's wort may increase risk of adverse reactions.
Mechanism of Actions
 Rizatriptan is a selective serotonin (5-HT1) agonist in cranial arteries responsible for vasoconstriction and reduction of inflammation associated with antidromic neuronal transmission.
Absorption: Bioavailability: about 40-45%.
Distribution: Protein binding: 14%.
Metabolism: Primarily by monoamine oxidase type A.
Excretion: About 14% of an oral dose is excreted unchanged in the urine. Plasma half-life: about 2-3 hr.
Administration
 Tab: May be taken with or without food.
Orally disintegrating tab: May be taken with or without food. (Place on the tongue & allow to dissolve; it can then be swallowed w/ the saliva.)
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 N02CC04 - rizatriptan ; Belongs to the class of selective serotonin (5HT1) agonists preparations. Used to relieve migraine.
Storage
 Oral: Store at 15-30°C.
Available As
  • Rizatriptan 10 mg
  • Rizatriptan 5 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Rizatriptan


    Rizatriptan Containing Brands

    We are Developing Our database, More results coming soon.

    Rizatriptan is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Rizatriptan

    We are Developing Our database, More results coming soon.