Uncomplicated premature labour
Adult: Start oral therapy 30-60 mins before termination of IV infusion at 10 mg every 2 hr for 24 hr. Subsequently, 10-20 mg every 4-6 hr according to patient's response. Max oral dose 120 mg daily.
Uncomplicated premature labour
Adult: Given as IV infusion, initially 0.05 mg/min. Increase by 0.05 mg/min every 10 min until patient responds. Usual rate: 0.15-0.35 mg/min. As IM inj: 10 mg every 3-8 hr. Maintain for 12-48 hr after the contractions have stopped.
Antepartum haemorrhage, eclampsia and severe preeclampsia, intrauterine foetal death, cardiac disease. Threatened miscarriage, placenta praevia and cord compression.
Warnings / Precautions
CV risk factors, concurrent steroids, hyperthyroidism, myocardial insufficiency, arrhythmias, hypertension, DM, bronchial asthma treated with beta-agonists, lactation. Monitor plasma glucose and potassium. Monitor maternal pulse throughout infusion; adjust rate to avoid maternal heart beat exceeding 140 beats/min. Monitor patient's hydration status to reduce risk of pulmonary oedema. Discontinue treatment if there are signs of pulmonary oedema.
Adverse Reactions
Tachycardia, palpitation, headache, nervousness, anxiety, nausea, vomiting.
Potentially Fatal: Rarely, anaphylaxis, arrhythmia, pulmonary oedema, hypokalaemia.
Overdose Reactions
May lead to tachycardia, CNS stimulation, hypokalaemia and hyperglycaemia.
Drug Interactions
May enhance neuromuscular blockade produced by pancuronium and vecuronium.
Potentially Fatal: Potassium-depleting drugs may increase risk of hypokalaemia.
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Mechanism of Actions
A selective β2-adrenoceptor agonist with its main action on the uterus, causing relaxation. It reduces the intensity and frequency of contractions. Heart rate is also increased while diastolic pressure is reduced. May cause bronchial relaxation but this is not clinically significant in its usage.
Absorption: Rapid absorption from the GI tract (oral). Bioavailability: about 30% of an oral dose.
Distribution: Crosses the placenta.
Metabolism: Hepatic: By conjugation with glucuronic acid or sulfate.
Excretion: 70-90% of a dose is excreted in the urine within 10-12 hr.
ATC Classification
G02CA01 - ritodrine ; Belongs to the class of sympathomimetics. Used as labour repressants.
Available As
  • Ritodrine 10 mg
  • Ritodrine 100 mg
  • Ritodrine 150 mg
  • Ritodrine 5 mg
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