Indications |
Oral Single or mixed infections due to susceptible worms Adult: 10 mg/kg as a single dose. Child: 10 mg/kg as a single dose. Oral Ascariasis Adult: 5 mg/kg as a single dose. Max: 1 g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr. Oral Necatoriasis Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days. Oral Enterobiasis Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose. Oral Trichinosis Adult: 10 mg/kg daily for 5 days. |
Warnings / Precautions |
Liver dysfunction, anaemia or severe malnutrition. Treat members in close contact with the patient. |
Adverse Reactions |
Anorexia, nausea, vomiting, abdominal cramps, drowsiness, insomnia, diarrhoea, tenesmus, SGOT elevations, headache, dizziness, rash. |
Drug Interactions |
Potentially Fatal: Mutually antagonistic with piperazine. See Below for More pyrantel Drug Interactions |
Mechanism of Actions |
Pyrantel is effective against roundworms (Ascaris), threadworms (Enterobius), hookworms and Trichostrongylus. Not effective against whipworm. Acts by paralysing the worms which get detached and are excreted by intestinal peristalsis. Absorption: Minimally absorbed from the GI tract (oral). Excretion: Via urine (7% as unchanged drug and metabolites), via faeces (>50% as unchanged). |
Administration |
May be taken with or without food. |
ATC Classification |
P02CC01 - pyrantel ; Belongs to the class of tetrahydropyrimidine derivative agents. Used as antinematodal. |
Available As |
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Pyrantel
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Pyrantel Containing Brands
Pyrantel is used in following diseases
Drug - Drug Interactions of Pyrantel
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