Prazosin

Indications
 Oral
Hypertension
Adult: As hydrochloride: Initially, 500 mcg bid-tid for 3-7 days, increased to 1 mg bid-tid for the next 3-7 days if tolerated, and gradually increased thereafter according to patient's response. Max dose: 20 mg daily.
Oral
Heart failure
Adult: As hydrochloride: Initially, 500 mcg bid-qid, gradually increased according to response. Maintenance: 4-20 mg daily.
Oral
Benign prostatic hyperplasia
Adult: Initially, 500 mcg bid, increased to a maintenance dose of ≤2 mg bid.
Oral
Raynaud's syndrome
Adult: Initially, 500 mcg bid, increased to a maintenance dose of ≤2 mg bid.
Contraindications
 Congestive heart failure due to mechanical obstruction. Hypersensitivity. Pregnancy.
Warnings / Precautions
 Angina pectoris. Ability to drive or operate machinery may be impaired. Phaeochromocytoma, abrupt withdrawal, impaired renal and liver function. child <12 yr. Lactation. May develop tolerance in prolonged treatment. Intiate treatment with low doses.
Adverse Reactions
 Postural hypotension, syncope, palpitations, lack of energy, nausea, oedema, chest pain, dyspnoea, constipation, diarrhoea, vomiting, depression, nervousness, sleep disturbances, headache, lassitude, drowsiness, loss of consciousness, dizziness, vertigo, hallucinations, paraesthesia, nasal congestion, epistaxis, dry mouth, urinary frequency and incontinence, pruritus, rash.
Potentially Fatal: Rarely, hypotension may be life-threatening.
Overdose Reactions
 Severe hypotension may occur. May be treated with activated charcoal if patient presents within 1 hr of ingestion.
Drug Interactions
 May increase plasma concentrations of digoxin. Antihypertensive effect enhanced by other antihypertensive drugs. Diuretics and alcohol. Risk of 1<207>st dose hypotension is increased in patients receiving β-blockers or calcium-channel blockers.
See Below for More prazosin Drug Interactions
Lab Interactions
 May give false-positive results in screening tests for pheochromocytoma.
Mechanism of Actions
 Prazosin competitively blocks postsynaptic α1-adrenoceptors of veins and arterioles causing vasodilation and reduction in blood pressure. The effect is seen in resistant vessels. There is no reflex tachycardia. Diastolic pressure reduced to a greater extent.
Absorption: Readily absorbed from the GIT; peak plasma concentrations after 1-3 hr (oral).
Distribution: Small amounts enter the breast milk. Protein-binding: High.
Metabolism: Extensively hepatic.
Excretion: Faeces (5-11% as unchanged drug; metabolites); urine (<10%); 2-4 hr (elimination half-life).
Administration
 May be taken with or without food. (Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or w/o meals.)
ATC Classification
 C02CA01 - prazosin ; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
Available As
  • Prazosin 1 mg
  • Prazosin 2 mg
  • Prazosin 2.5 mg
  • Prazosin 5 mg

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    One Response to Prazosin

    1. August 1, 2013 at 9:34 pm #

      please inform me you that, prazopress xl 2.5mg dose of scorpion bite in children

      Reply

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