Podophyllotoxin

Indications
Topical/Cutaneous
Anogenital warts
Adult: On a wkly basis, apply 15% (Indian podophyllum) or up to 25% solution (American podophyllum) on the warts, leave for 1-6 hr then wash off. If there is no improvement after 6 wk, stop treatment. Alternatively, apply 0.5% alcoholic gel or 0.15% cream bid for 3 days but do not wash off. Repeat wkly for up to 5 wk.
Contraindications
Hypersensitivity; pregnancy; lactation; child.
Warnings / Precautions
Avoid excessive application. Avoid contact with eyes and inflamed skin. Not to be used on cervical or urethral warts.
Adverse Reactions
Irritating to the eyes and mucous membranes; GI disturbances; thrombocytopenia, leucopenia; renal failure; hepatotoxicity; CNS effects; EEG changes; peripheral and autonomic neuropathies; local reactions.
Mechanism of Actions
Podophyllotoxin has an antimitotic action and is used mainly as a topical treatment for anogenital warts.
ATC Classification
D06BB04 - podophyllotoxin ; Belongs to the class of topical antivirals used in the treatment of dermatological diseases.
Available As
  • Podophyllotoxin 5 mg
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