As monotherapy in Parkinson's disease
Adult: Monotherapy: 150-250 mg daily in divided doses. In combination with levodopa therapy: 80-140 mg daily.
Circulatory disorders
Adult: 50 mg daily or 100 mg daily in 2 divided doses for severe cases.
Hypersensitivity, CV collapse, acute myocardial infarction, uncontrolled hypertension, pregnancy.
Warnings / Precautions
Raynaud's syndrome, history of psychosis, renal impairment. May cause hypotension in the first few days of treatment. Regular ophthalmological monitoring is recommended. Lactation.
Adverse Reactions
Nausea, vomiting, dizziness, confusion, drowsiness, hypothermia, dyskinesias, occasional changes in liver function. Raynaud's syndrome or digital vasospasm, leg cramps.
Drug Interactions
Clonidine and dopamine antagonists eg, phenothiazines and haloperidol may antagonise effects of piribedil.
See Below for More piribedil Drug Interactions
Mechanism of Actions
Piribedil is a non-ergot dopamine D2 agonist that stimulates cerebral and peripheral dopamine receptors and corrects dopamine deficiency. It is used largely, as an adjunct to levodopa therapy in the treatment of Parkinson's disease.
Should be taken with food. (Take at the end of a main meal.)
ATC Classification
N04BC08 - piribedil ; Belongs to the class of dopamine agonists. Used in the management of Parkinson's disease.
Available As
  • Piribedil 50 mg
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