Phthalyl Sulphathiazole

Indications
 Oral
Susceptible infections, Bowel decontamination before surgery
Adult: In combination with other antibacterials. Use as directed by product information.
Renal impairment: Dose reduction may be necessary.
Contraindications
 Pregnancy (prior to delivery); infants within 1-2 mth of birth; porphyria; severe renal or hepatic failure; blood disorders; hypersensitivity; SLE.
Warnings / Precautions
 Adequate hydration is necessary to reduce the risk of crystalluria. Discontinue immediately if rash appears. Renal or hepatic failure; asthma or history of allergy; elderly; G6PD deficiency; AIDS patients (especially those on trimethoprim).
Adverse Reactions
 GI effects, hypersensitivity reactions, nephrotoxic reactions, blood disorders, hepatic disorders, CV effects, hypoglycaemia, hypothyroidism, neurological reactions, pseudomembranous colitis and kernicterus in premature neonates.
Potentially Fatal: Toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylaxis.
Drug Interactions
 Potentiates effect of oral anticoagulants, methotrexate and phenytoin; possible failures of hormonal contraceptives; enhanced antidiabetic effect of sulfonylurea compounds; antagonism with PABA and its derivatives; associated with decrease in plasma ciclosporin concentrations.
See Below for More phthalylsulfathiazole Drug Interactions
Lab Interactions
 Urea, creatinine and urinary glucose and urobilinogen.
Mechanism of Actions
 Phthalylsulfathiazole is a sulfonamide with properties similar to those of sulfamethoxazole. Sulfonamides have a similar structure to p-aminobenzoic acid (PABA) and interfere with the nucleic acid synthesis in sensitive microorganisms by blocking the conversion of PABA to the reduced form of folic acid, co-enzyme dihydrofolic acid. Primarily bacteriostatic, it may exert bactericidal effects where concentrations of thymine are low in surrounding medium. It is used to treat infections and for bowel decontamination before surgery.
Absorption: Poorly absorbed, approx 95% remaining in the intestine.
Metabolism: Slowly hydrolysed to sulfathiazole.
ATC Classification
 A07AB02 - phthalylsulfathiazole ; Belongs to the class of sulfonamide antiinfectives. Used in the treatment of intestinal infections.
Available As
  • Phthalyl Sulphathiazole 167 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Phthalyl Sulphathiazole


    Phthalyl Sulphathiazole Containing Brands

    We are Developing Our database, More results coming soon.

    Phthalyl Sulphathiazole is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Phthalyl Sulphathiazole

    We are Developing Our database, More results coming soon.