Phenindione

Indications
 Oral
Thromboembolic disorders
Adult: Initially, 200 mg in 2 equal doses on day 1 followed by 100 mg on day 2. Maintenance: 50-150 mg daily depending on coagulation tests.
Contraindications
 Hypersensitivity. Predisposition to severe haemorrhage (e.g. ulceration or bleeding in the GI, genitourinary or respiratory tract, haemorrhagic blood dyscrasias, haemophilia, threatened abortion, presence of extensive surgical wounds). Pregnancy.
Warnings / Precautions
 Severely impaired renal or hepatic function, severe hypertension, patients who will undergo surgery (including dental extraction), CHF, female patients >60 yr. Monitor prothrombin time regularly. Lactation.
Adverse Reactions
 Haemorrhage. Skin rash, pyrexia, diarrhoea, vomiting, sore throat. Rarely, skin necrosis. May colour urine pink or orange.
Potentially Fatal: Hypersensitivity reactions e.g. exfoliative dermatitis, liver and kidney damage, myocarditis, agranulocytosis, leucopenia, eosinophilia, leukaemoid syndrome.
Overdose Reactions
 Symptoms: Early signs include bleeding from the gums or haematuria. Treatment: Withdraw the drug to stop mild bleeding and to normalise prothrombin time. For more severe haemorrhage, administer IV vitamin K1. Fresh whole blood or frozen plasma transfusion may also be necessary for severe haemorrhage.
Drug Interactions
 Reduced effect with haloperidol. Increased effect with clofibrate. Increased prothrombin levels with co-trimoxazole. May increase toxicity of chlorpropamide, phenytoin, sulfonamides and tolbutamide. Potential increase in anticoagulant effects: Alcohol, anaesthetics, antithyroids, aspirin and salicylates, aztreonam, bretylium, cathartics, cimetidine, ciprofloxacin, dextran, disulfiram, ethacrynic acid, fibrinolysin, gemfibrozil, glucagon, guanethidine, heparin, iodine, methaqualone, methotrexate, methyldopa, methylphenidate, nalidixic acid, nicotinic acid, NSAIDs, paracetamol, phenothiazines, phenytoin, probenecid, quinine, quinidine, sulfinpyrazone, thyroid hormones, tolbutamide, vitamin B complex, X-ray contrast media. Potential decrease in anticoagulant effects: Antacids, antihistamines, barbiturates, bioflavonoids, digitalis glycosides, diuretics, ethchlorvynol, fibrinogen, glutethimide, griseofulvin, haloperidol, meprobamate, oral contraceptives, thrombin, trifluperidol, vitamin K, xanthines.
See Below for More phenindione Drug Interactions
Lab Interactions
 May colour urine pink or orange interfering with some urinary tests.
Mechanism of Actions
 Phenindione is an indanedione anticoagulant. It acts by antagonising the effects of vitamin K.
Absorption: Well absorbed from the GI tract (oral).
Distribution: Crosses the placenta and enters breast milk.
Excretion: Via urine (as metabolites).
ATC Classification
 B01AA02 - phenindione ; Belongs to the class of vitamin K antagonists. Used in the treatment of thrombosis.
Available As
  • Phenindione 50 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Phenindione


    Phenindione Containing Brands

    We are Developing Our database, More results coming soon.

    Phenindione is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Phenindione

    We are Developing Our database, More results coming soon.