Phenformin

Indications	Oral Type 2 diabetes mellitus *Adult:* 200-400 mg bid.
Contraindications	Insulin-dependent diabetes, diabetic coma, ketoacidosis, trauma, severe infection, heart failure, recent MI; dehydration. Renal or hepatic impairment.
Warnings / Precautions	Monitor vitamin B₁₂ concentrations annually during long-term treatment. Pregnancy.
Adverse Reactions	Anorexia, nausea, vomiting, diarrhoea, metallic taste, wt loss, skin reactions, acute pancreatitis. Potentially Fatal: Lactic acidosis, CV adverse effects.
Overdose Reactions	Symptoms: Lactic acidosis. Treatment: Intensive supportive therapy. Glucose or glucagon may be given if hypoglycaemia is present.
Drug Interactions	May impair vitamin B₁₂ absorption. Potentially Fatal: Cimetidine may reduce renal clearance of phenformin. Increased risk of lactic acidosis with alcohol, nephrotoxic drugs. See Below for More phenformin Drug Interactions
Mechanism of Actions	Phenformin is a biguanide antidiabetic. It does not stimulate insulin release but requires the presence of insulin to exhibit its hypoglycaemic effect. It delays glucose absorption from the GI tract, increases insulin sensitivity and glucose uptake, and inhibits gluconeogenesis in the liver. Metabolism: Hepatic.
Available As	Phenformin 25 mg Phenformin 50 mg

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Phenformin Containing Brands

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Phenformin is used in following diseases

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Drug - Drug Interactions of Phenformin

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