Phenazopyridine

Indications
 Oral
Pain and irritability in cystitis, prostatitis and urethritis
Adult: As hydrochloride: 200 mg tid. When combined with an antibiotic, max duration of treatment is 2 days, although lower doses for at least a wk have been given.
Child: As hydrochloride: 12 mg/kg/day in 3 divided doses for 2 days.
CrCl (ml/min)Dosage Recommendation
50-80Give dose every 8-16 hr.
<50Avoid.
Contraindications
 Impaired renal function or severe hepatitis. CrCl <50 ml/min.
Warnings / Precautions
 Avoid prolonged use. Pregnancy and lactation. G6PD deficiency. Stop treatment if skin or sclerae discolouration occur. Elderly.
Adverse Reactions
 GI disturbances, headache; rash; hepatotoxicity; haemolytic anaemia, methaemoglobinaemia; discolouration of urine and other body fluids; staining of contact lens; crystal deposits in urinary tract.
Potentially Fatal: Acute renal failure.
Overdose Reactions
 Symptoms: Methaemoglobinaemia, haemolytic anaemia, skin pigmentation, renal and hepatic impairment. Treatment: Use methylene blue for methaemoglobinaemia.
Lab Interactions
 May interfere with urine ketone and protein tests. May delay reactions with glucose oxidase reagents. May occasionally cause false-positive tests with Tes-Tape.
Mechanism of Actions
 Phenazopyridine is an azo dye that exerts an analgesic effect in the urinary tract.
Absorption: Absorbed from the GI tract (oral).
Excretion: Via urine (65% as unchanged drug; 18% as paracetamol).
Administration
 Should be taken with food. (Take after meals.)
ATC Classification
 G04BX06 - phenazopyridine ; Belongs to the class of other urologicals.
Available As
  • Phenazopyridine 100 mg
  • Phenazopyridine 200 mg

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