Phenazone

Indications
 Oral
Mild to moderate pain
Adult: 500 mg to 1 g every 4-8 hr. Max: 4 g/day.
Child: 12-15 yr: 500 mg once or bid. Max: 1 g daily. >15 yr: 500 mg to 1 g every 4-8 hr. Max: 4 g/day.
Oral
Acute migraine attacks
Adult: 1 g every 4-8 hr. Max: 4 g/day.
Child: >15 yr: 1 g every 4-8 hr. Max: 4 g/day.
Otic/Aural
Otic inflammation
Adult: 4-6 drops (0.5% solution) 3-4 times daily depending on the severity of inflammation.
Otic/Aural
Removal of earwax
Adult: 4-6 drops (0.5% solution) 3-4 times daily depending on the severity of inflammation.
Contraindications
 Allergy to pyrazolones or other NSAIDs. G6PD deficiency, porphyria. Otic/Aural: Perforated eardrums.
Warnings / Precautions
 Pregnancy. History of blood disorders.
Adverse Reactions
 Hypersensitivity reactions, nephrotoxicity. Nausea, drowsiness, convulsive crisis, agranulocytosis, leucopenia.
Potentially Fatal: Coma (large oral doses), severe skin eruptions.
Drug Interactions
 May affect metabolism of drugs metabolised by liver enzymes. Metabolism may be affected by liver enzyme inhibitors or inducers.
See Below for More phenazone Drug Interactions
Mechanism of Actions
 Phenazone is an NSAID.
Absorption: Absorbed from the GI tract. Peak plasma concentrations within 1-2 hr.
Distribution: Throughout the body fluids; concentrations in the saliva and breast milk reaching about the same levels as those in plasma. Protein-binding: <10%.
Metabolism: Hepatic; metabolised to 3 major metabolites.
Excretion: Mainly via urine; via bile (small amount). Elimination half-life: About 12 hr.
Storage Conditions
 Otic/Aural: Store below 25°C.
ATC Classification
 N02BB01 - phenazone ; Belongs to the class of pyrazolone preparations. Used to relieve pain and fever.
Storage
 Otic/Aural: Store below 25°C.
Available As
  • Phenazone 50% w/v

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