Pentosan Polysulphate Sodium

Indications
 Oral
Interstitial cystitis
Adult: 100 mg tid.
Contraindications
 Patients who are haemorrhaging. Serious renal or hepatic impairment. Not to be given via IM inj.
Warnings / Precautions
 Patients with spleen disorders, hepatic or renal impairment. Monitor platelet counts during treatment. To discontinue treatment if thrombocytopenia occurs. Caution when used in patients with haemorrhagic blood disorders, thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, bacterial endocarditis, severe hypertension or oesophageal varices. Recent surgery at sites where haemorrhage would be an especial risk. Safety not established in children <16 yr. Patients should be monitored every 3 mth; risks and benefits after 6 mth of treatment not known. Pregnancy; lactation.
Adverse Reactions
 Local irritation, skin necrosis; alopecia and osteoporosis may occur upon prolonged treatment; hyperkalaemia and bleeding; nausea, diarrhoea, headache, fatigue, drowsiness, pelvic pain, rectal haemorrhage, dyspepsia, abdominal pain; LFT abnormalities.
Overdose Reactions
 Symptoms: Anticoagulation, bleeding, thrombocytopenia, liver function abnormalities and gastric distress. Treatment: Gastric lavage and symptomatic and supportive therapy.
Drug Interactions
 Increased risk of bleeding when used with oral anticoagulants or drugs that affect platelet function. Concurrent admin with glyceryl trinitrate via IV route may reduce the efficacy of pentosan.
See Below for More pentosan polysulfate sodium Drug Interactions
Mechanism of Actions
 Pentosan polysulfate sodium is a heparinoid with anticoagulant and fibrinolytic properties; it may also have hypolipidaemic and anti-inflammatory effects. It is used in thromboembolic disorders, although its anticoagulant effect is less than that of heparin. It is also used in the management of interstitial cystitis and has been tried in a number of other conditions, including variant Creutzfeldt-Jakob disease.
Absorption: Approx 6%.
Metabolism: Hepatic and via spleen; some in renal parenchyma.
Excretion: Half-life elimination: 20-27 hr. Excretion via urine (6%, mainly as metabolites); faeces (58-84%, as unchanged drug).
Administration
 Should be taken on an empty stomach. (Take at least 1 hr before or 2 hr after meals.)
Storage Conditions
 Oral: Store at 15-30 °C.
ATC Classification
 C05BA04 - pentosan polysulfate sodium ; Belongs to the class of heparins or heparinoids used topically in antivaricose therapy.
Storage
 Oral: Store at 15-30 °C.
Available As
  • Pentosan Polysulphate Sodium 100 mg

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