Parvastatin Sodium

Indications
 Oral
Hyperlipidaemias
Adult: As sodium: 10-40 mg daily at night, adjusted according to response at 4-wk intervals. Max dose: 40 mg daily.
Child: (With familial hypercholestrolaemia) 8-13 yr: 10-20 mg, 14-18 yr: 10-40 mg, dose to be taken once daily.
Renal impairment: Moderate to severe: initial dose should not exceed 10 mg daily.
Hepatic impairment: Significant impairment: initial dose should not exceed 10 mg daily.
Contraindications
 Hypersensitivity; active liver disease; childn <8 yr. Pregnancy, lactation.
Warnings / Precautions
 Severe intercurrent illness increases risk of myopathy, rhabdomyolysis and renal failure; stop pravastatin during illness. Severe renal impairment, monitor regularly renal function and creatine kinase. Women of childbearing potential, use adequate contraception. Preexisting abnormal liver function, monitor serum transaminase. Children. May increase creatine phosphokinase and transaminases levels.
Adverse Reactions
 GI symptoms, headache, insomnia, chest pain, rash, fatigue, dizziness, myalgia, hypersensitivity, anaphylaxis, angioedema, rhabdomyolysis, renal failure, hepatitis, alopoecia, paraesthesia, impotence, gynaecomastia.
Drug Interactions
 Fenofibrate, clofibrate, nicotinic acid and gemfibrozil increase risk of myopathy or rhabdomyolysis, use lowest effective dose. Ciclosporin, clarithromycin, itraconazole, ketoconazole and erythromycin increase pravastatin concentrations. Increased risk of bleeding when used with coumarins and fluindione. Decreased serum concentrations when used with efavirenz and rifampicin.
See Below for More pravastatin Drug Interactions
Mechanism of Actions
 Pravastatin inhibits HMG-CoA reductase, the enzyme which catalyses the rate-limiting step in cholesterol biosynthesis. It reduces conc of total cholesterol and LDL (LDL) cholesterol and triglyceride. It produces an increase in high-density lipoprotein (HDL) cholesterol and it increases hepatic cholesterol uptake from blood.
Absorption: Rapidly but incompletely absorbed from the GIT (oral). Absolute bioavailability is about 17%.
Distribution: Protein-binding: 50%
Metabolism: Extensively hepatic.
Excretion: Faeces (70%); urine (20%); 1.5-2 hr (elimination half-life).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 C10AA03 - pravastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Storage
 Oral: Store at 25°C.
Available As
  • Parvastatin Sodium 10 mg
  • Parvastatin Sodium 20 mg

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