Oxazepam

Indications
 Oral
Alcohol withdrawal syndrome
Adult: 15-30 mg 3 or 4 times daily.
Elderly: or debilitated patients: Initially, 10 mg tid; increase up to 10-20 mg 3 or 4 times daily as necessary.
Oral
Anxiety
Adult: 15-30 mg 3 or 4 times daily.
Elderly: or debilitated patients: Initially, 10 mg tid; increase up to 10-20 mg 3 or 4 times daily as necessary.
Oral
Insomnia associated with anxiety
Adult: 15-25 mg given 1 hr before bedtime. Up to 50 mg may be occasionally required.
Contraindications
 Not for the treatment of psychoses. Pregnancy and lactation.
Warnings / Precautions
 Cross-sensitivity with other benzodiazepines may occur. Hepatic and renal impairment. Respiratory disease. Debilitated patients, elderly, patients at risk of falls. Withdraw gradually. Porphyria; impaired gag reflex. History of drug abuse or acute alcoholism. May impair ability to drive or operate machinery. CV or cerebrovascular disease, intolerance to transient decreases in BP. Depression or if suicidal risk is present.
Adverse Reactions
 Syncope (rare), oedema; drowsiness, ataxia, dizziness, vertigo, memory impairment, headache, paradoxical reactions (excitement, stimulation of effect), lethargy, amnesia, euphoria; rash; decreased libido, menstrual irregularities; incontinence; leukopenia, blood dyscrasias; jaundice; dysarthria, tremor, reflex slowing; blurred vision, diplopia; drug dependence.
Overdose Reactions
 Symptoms: Somnolence, confusion, coma, hypoactive reflexes, dyspnoea, hypotension, slurred speech, impaired coordination. Treatment: Supportive.
Drug Interactions
 Reduced sedative effects with theophylline and other CNS stimulants. Increased incidence of headache with zidovudine. May reduce effects of levodopa.
Potentially Fatal: Additive CNS depression with alcohol and other CNS depressants.
See Below for More oxazepam Drug Interactions
Food Interactions
 Additive CNS depression may occur with valerian, St John's wort, kava kava, gotu kola.
Mechanism of Actions
 Oxazepam is a short-acting benzodiazepine. It enhances the activity of GABA, a major inhibitory neurotransmitter in the brain, by binding to specific sites in the GABA receptors.
Absorption: Well absorbed from the GI tract; peak plasma levels in about 2 hr (oral).
Distribution: Crosses the placenta and detected in breast milk. Protein-binding: 85-97%.
Metabolism: Hepatic; extensively metabolised to inactive glucuronide.
Excretion: Via urine as unchanged drug and inactive metabolites. Elimination half-life: 3-21 hr.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 15-30°C (59-86°F).
ATC Classification
 N05BA04 - oxazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Storage
 Oral: Store at 15-30°C (59-86°F).
Available As
  • Oxazepam 10 mg
  • Oxazepam 15 mg
  • Oxazepam 30 mg

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